The Centro de Investigación en Salud de Manhiça (CISM) was the country’s first high-level research centre for tropical diseases. It was founded in 1996 within the framework of the intergovernmental agreements signed between Spain and Mozambique. The mission of the centre, which is funded by the Spanish Agency for International Cooperation (AECI), is to help improve the health of the population and develop the country through health care, technical support for Mozambique’s Ministry of Health, staff training and research into the priority health problems in the area. Recently, the research group from the Clínic Hospital of Barcelona / Barcelona University / IDIBAPS has developed a new strategy for controlling malaria, the results of which were published in The Lancet. The study, conducted in Tanzania, has had wide repercussions on public opinion and the scientific community. The success of the project has prompted the WHO to promote the trial of this new strategy in other countries in sub-Saharan Africa. For this purpose, it has chosen Mozambique, and has specifically selected the CISM as the pilot research centre, with the Clínic Hospital of Barcelona acting as the IPTI Consortium Global Co-ordinating Centre.